منابع مشابه
Reduced serum vitamin B-12 in patients taking metformin.
Josep Vidal-Alaball honorary research fellow [email protected] Christopher C Butler professor of primary care medicine, Department of Primary Care and Public Health, Heath Park, Cardiff CF14 4YS Competing interests: All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure. pdf (available on request from the corresponding author) and declare: (1) No fi...
متن کاملVitamin B-12.
V itamin B-12 is a cofactor for 2 enzymes. In the cytoplasm, methionine synthase requires vitamin B-12 in the form of methylcobalamin and catalyzes the conversion of homocysteine to methi-onine by transfer of a methyl group from methyltet-rahydrofolate. This enzyme links the methylation pathway through synthesis of the methyl donor S-adenosyl methionine and the pathway in which purine and pyrim...
متن کاملLongitudinal concentrations of vitamin B(12) and vitamin B(12)-binding proteins during uncomplicated pregnancy.
BACKGROUND Because reference values for vitamin B(12) concentrations and vitamin B(12)-binding capacities for pregnant women have not been established, the reference values for nonpregnant women are often applied to assess vitamin B(12) status. The aim of the present study was to describe ranges of biochemical indices of vitamin B(12) status, including red blood cell (RBC) vitamin B(12), satura...
متن کاملThe Vitamin B 12 Coenzyme
INTRODUCTION In 19'58 Barker and his associates l 3 recognized a new coenzyme which controlled the conversion of glutamate into ,8-methylaspartate by Clostridium tetanomorph'im. The coenzyme was shown4 to be related to ",-vitamin B12, i.e. contair ing an adenine nucleotide grouping in place of the 5,6-dimethylbe:nziminalole nucleotide of vitamin B12, although similar coenzymes containing b{ nzi...
متن کاملVitamin B(12) in type 2 diabetic patients treated with metformin.
OBJECTIVE To test vitamin B12 plasma levels in type 2 diabetic patients treated with metformin in our area. METHODS A cross-sectional, observational study of consecutive type 2 diabetic patients on drug treatment attending an internal medicine outpatient clinic. RESULTS One hundred and nine patients (81 treated with metformin) were enrolled into the study. Mean time on metformin treatment w...
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ژورنال
عنوان ژورنال: BMJ
سال: 1971
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5768.246-b